High Blood Pressure (Hypertension)
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High Blood Pressure (Hypertension)
QGC001-3QG1 Enrolling

Research Trial for Hypertension (20 Weeks)


Age: 18 Years

 

Adults (men or women) aged 18 years and older with a diagnosis of primary hypertension for at least 6 months, may qualify to participate. Individuals must currently be treated with at least 2 antihypertensive classes of drug (including a diuretic) at the maximum tolerated doses. Systolic BP between 140 mmHg and 170 mmHg (inclusive) at screening, while on current chronic antihypertensive treatments, is also required.

Participants will receive investigational oral medication (active study drug) or placebo. Investigational medication and study-related care will be provided at no cost. Reimbursement for study-related expenses may be provided.

Study participation will last about 20 weeks and involve about 8 visits to the study centre, plus 1 phone visit.


Official Title

A Phase 3, Double-blind, Placebo-controlled, Efficacy and Safety Study of Firibastat (QGC001) Administered Orally, Twice Daily, Over 12 Weeks in Difficult-to-treat/Resistant Hypertensive Subjects

ClinicalTrials.gov ID

NCT04277884

Sponsor

Quantum Genomics SA

Study Description

  • Brief Summary:

    Quantum Genomics SA

  • Condition or Disease:

    Hypertension

  • Intervention/Treatment:

    Drug: Firibastat Drug: Placebo
  • Phase:

    Phase 3

  • Ages Eligible for Study:

    18 Years and older (Adult,Older Adult)

  • Sexes Eligible for Study:

    All

Inclusion Criteria:

Men and women ≥18 years of age at Screening
Diagnosis of primary HTN for at least 6 months prior to Screening

Exclusion Criteria:

Known or suspected secondary HTN (eg, hyperaldosteronism, renovascular HTN, pheochromocytoma, Cushing’s disease).
Automated office SBP >170 mmHg or DBP >110 mmHg at the Screening or Inclusion Visit (Visit 2, Day 1) and confirmed by a second measurement within 30 minutes to 1 hour.
Known hypertensive retinopathy (Keith-Wagener Grade 3 or Grade 4) and/or hypertensive encephalopathy.


Participating Locations

COUNTRY
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Canada

Participating Experts

Dr. Michael Hartleib, MSc, MD, FRCPC

Cardiologist

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High Blood Pressure (Hypertension)

Adults (men or women) aged 18 years and older with a diagnosis of primary hypertension for at least 6 months, may... Learn More
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