Psoriasis
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Psoriasis
ESK-001-006 Enrolling

Plaque Psoriasis – Research Trial (20 Weeks)


Treatment: Oral Age: 18 Years

Adults aged 18-75 years with a diagnosis of plaque psoriasis for 6 months or more and a weight of 40 kg (88 lbs) or more are needed for this clinical research trial.  Eligible participants must have moderate to severe disease with plaques covering 10% or more of the body surface area (BSA).

Participants will receive investigational oral treatment (active study drug) or placebo, via tablet form.  Study medication and study-related assessments will be provided at no cost.  Reimbursement for study-related expenses (such as travel and accomodations) may be provided.

Study participation will last about 20 weeks and involve about 9 visits to the study centre.


The following information is from ClinicalTrials.gov

Last Update Posted: January 29, 2023

Official Title

A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of ESK-001 in Patients With Moderate to Severe Plaque Psoriasis

ClinicalTrials.gov ID

NCT05600036

Sponsor

Alumis Inc

Study Description

  • Brief Summary:

    This is a multi-center, randomized, double-blind, placebo-controlled study in patients with moderate to severe plaque psoriasis.

  • Condition or Disease:

    Plaque Psoriasis

  • Intervention/Treatment:

    Drug: ESK-001
    Drug: ESK-001
    Drug: ESK-001
    Drug: ESK-001
    Drug: ESK-001
    Drug: Placebo
  • Phase:

    Phase 2

  • Ages Eligible for Study:

    18 Years and 75 Years (Adult)

  • Sexes Eligible for Study:

    All

Inclusion Criteria:

Total body weight >40 kg (88 lb)
Men and woman age 18-75
Men and Women must use highly effective methods of contraception for the entirety of the study

Exclusion Criteria:

History of malignancy within the last 5 years
Positive for HIV, Hepatitis B or C
History of tuberculosis
Diagnosis of non-plaque psoriasis
Patients with QTcF >450 msec (males) or >470 msec (females) at screening
Live vaccines


Terms and Conditions – ClinicalTrials.gov
Purpose of ClinicalTrials.gov Database. The U.S. National Institutes of Health, Department of Health and Human Services, through its National Library of Medicine, has developed ClinicalTrials.gov to provide patients, family members, and members of the public current information about clinical research studies.


Participating Locations

COUNTRY
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Canada

Participating Experts

Dr. Kim Alexander Papp

Dermatologist

Dr. Maxwell Sauder

Dermatologist

Dr. Anatoli Freiman

Dermatologist

Dr. Benjamin Barankin

Dermatologist

Dr. Les A. Rosoph

Dermatologist

Dr. Mark Lomaga

Dermatologist

Dr. Lorne Albrecht

Dermatologist

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