ESK-001-006 Enrolling

Plaque Psoriasis – Research Trial (20 Weeks)

Treatment: Oral Age: 18 Years

Adults aged 18-75 years with a diagnosis of plaque psoriasis for 6 months or more and a weight of 40 kg (88 lbs) or more are needed for this clinical research trial.  Eligible participants must have moderate to severe disease with plaques covering 10% or more of the body surface area (BSA).

Participants will receive investigational oral treatment (active study drug) or placebo, via tablet form.  Study medication and study-related assessments will be provided at no cost.  Reimbursement for study-related expenses (such as travel and accomodations) may be provided.

Study participation will last about 20 weeks and involve about 9 visits to the study centre.

The following information is from

Last Update Posted: January 29, 2023

Official Title

A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of ESK-001 in Patients With Moderate to Severe Plaque Psoriasis ID



Alumis Inc

Study Description

  • Brief Summary:

    This is a multi-center, randomized, double-blind, placebo-controlled study in patients with moderate to severe plaque psoriasis.

  • Condition or Disease:

    Plaque Psoriasis

  • Intervention/Treatment:

    Drug: ESK-001
    Drug: ESK-001
    Drug: ESK-001
    Drug: ESK-001
    Drug: ESK-001
    Drug: Placebo
  • Phase:

    Phase 2

  • Ages Eligible for Study:

    18 Years and 75 Years (Adult)

  • Sexes Eligible for Study:


Inclusion Criteria:

Total body weight >40 kg (88 lb)
Men and woman age 18-75
Men and Women must use highly effective methods of contraception for the entirety of the study

Exclusion Criteria:

History of malignancy within the last 5 years
Positive for HIV, Hepatitis B or C
History of tuberculosis
Diagnosis of non-plaque psoriasis
Patients with QTcF >450 msec (males) or >470 msec (females) at screening
Live vaccines

Terms and Conditions –
Purpose of Database. The U.S. National Institutes of Health, Department of Health and Human Services, through its National Library of Medicine, has developed to provide patients, family members, and members of the public current information about clinical research studies.

Participating Locations


Participating Experts

Dr. Kim Alexander Papp


Dr. Maxwell Sauder


Dr. Anatoli Freiman


Dr. Benjamin Barankin


Dr. Les A. Rosoph


Dr. Mark Lomaga


Dr. Lorne Albrecht


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