Adults aged 18-75 years with a diagnosis of plaque psoriasis for 6 months or more and a weight of 40 kg (88 lbs) or more are needed for this clinical research trial. Eligible participants must have moderate to severe disease with plaques covering 10% or more of the body surface area (BSA).
Participants will receive investigational oral treatment (active study drug) or placebo, via tablet form. Study medication and study-related assessments will be provided at no cost. Reimbursement for study-related expenses (such as travel and accomodations) may be provided.
Study participation will last about 20 weeks and involve about 9 visits to the study centre.
The following information is from ClinicalTrials.gov
Last Update Posted: January 29, 2023
NCT05600036
Alumis Inc
Brief Summary:
This is a multi-center, randomized, double-blind, placebo-controlled study in patients with moderate to severe plaque psoriasis.
Condition or Disease:
Plaque Psoriasis
Intervention/Treatment:
Drug: ESK-001Phase:
Phase 2
Ages Eligible for Study:
18 Years and 75 Years (Adult)
Sexes Eligible for Study:
All
Inclusion Criteria:
Total body weight >40 kg (88 lb)
Men and woman age 18-75
Men and Women must use highly effective methods of contraception for the entirety of the study
Exclusion Criteria:
History of malignancy within the last 5 years
Positive for HIV, Hepatitis B or C
History of tuberculosis
Diagnosis of non-plaque psoriasis
Patients with QTcF >450 msec (males) or >470 msec (females) at screening
Live vaccines
Terms and Conditions – ClinicalTrials.gov
Purpose of ClinicalTrials.gov Database. The U.S. National Institutes of Health, Department of Health and Human Services, through its National Library of Medicine, has developed ClinicalTrials.gov to provide patients, family members, and members of the public current information about clinical research studies.
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