Heart Attacks
Heart Attacks
CSL112_3001 Enrolling

Heart Attack Research Study (12 Months)

Age: 18 Years

Official Title

A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Investigate the Efficacy and Safety of CSL112 in Subjects With Acute Coronary Syndrome

ClinicalTrials.gov ID



CSL Behring

Study Description

  • Brief Summary:

    CSL Behring

  • Condition or Disease:

    Acute Coronary Syndrome

  • Intervention/Treatment:

    Biological: Apolipoprotein A-I [human] (apoA-I) Other: Placebo
  • Phase:

    Phase 3

  • Ages Eligible for Study:

    18 Years and older (Adult,Older Adult)

  • Sexes Eligible for Study:


Inclusion Criteria:

Male or female least 18 years of age
Evidence of myocardial necrosis, consistent with type I (spontaneous) MI
No suspicion of acute kidney injury
Evidence of multivessel coronary artery disease

Presence of established cardiovascular risk factor(s):

Diabetes mellitus on pharmacotherapy OR
2 or more of the following: age ≥ 65 years, prior history of MI, peripheral arterial disease

Exclusion Criteria:

Ongoing hemodynamic instability
Evidence of hepatobiliary disease
Evidence of severe chronic kidney disease
Plan to undergo scheduled coronary artery bypass graft surgery as treatment for the index MI
Known history of allergies, hypersensitivity, or deficiencies to soy bean, peanut or albumin

Participating Locations


Participating Experts

Dr. Michael Hartleib, MSc, MD, FRCPC


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