Research Trial for Uncontrolled Asthma (64 Weeks)

Adolescents and adults at least 12 years of age or older with a documented physician diagnosis of asthma for 2 years or more, may qualify to participate. Individuals must have an eosinophilic phenotype (meaning their asthma is not being controlled with the usual asthma medications) AND have a previously confirmed history of 2 or more exacerbations requiring treatment with systemic corticosteroid (IM, IV or oral) in the 12 months prior to Visit 1, despite the use of medium to high dose inhaled corticosteroid. Persistent airflow obstruction will also be assessed.

Individuals with a well documented requirement for regular treatment with medium to high dose inhaled corticosteroid (in the 12 months prior to Visit 1, with or without maintenance oral corticosteroid), will be considered. Note: individuals treated with medium dose inhaled corticosteroid will need to be treated with Long-Acting β2-Agonist (LABA) to qualify. Treatment with at least one additional controller medication is also required.

Current smokers or former smokers (who stopped smoking at least 6 months prior to Visit 1) with a smoking history of 10 pack years or more, need not apply.

Participants will receive investigational medication (active study drug) or placebo via subcutaneous injection. Study medication and study-related care will be provided at no cost. Reimbursement for study-related expenses will also be provided.

Study participation will last about 64 weeks and involve about 19 visits to the study centre, which may include a follow-up phone call.

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If there are no active studies for your condition, we will keep your information and contact you when a new study starts in your area.

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Why Take Part In a Clinical Study?

Regulatory agencies like Health Canada, Australia's Therapeutic Goods Administration and the FDA require that Clinical Research Trials be conducted in order to develop new treatments, preventions and devices for diseases or conditions. Clinical Research Trials are also referred to as Clinical Studies or Clinical Trials. read more