Heart Failure Research Trial (19-43 Months)

The purpose of this study is to look at how well the investigational medication reduces the number of hospital visits and death related to heart failure.

Adults (male or female) aged 40 years and older with a diagnosis of heart failure (NYHA class II-IV), either capable of walking or hospitalized, may qualify to participate. Individuals must have documented LVEF (left ventricular ejection fraction) of ≥ 40% measured within the last 12 months (or a measurement may be done at screening). Treatment with diruretics within 30 days prior to study randomization, and structural heart abnormalities based on local imaging measurement within the last 12 months (or performed at screening), is also required.

Participants will receive investigational oral medication (active study drug) or placebo. Investigational medication and study-related care will be provided at no cost. Reimbursement for study-related expenses may be provided.

Length of study participation (including treatment duration and follow-up) is expected to last between 19 and 43 months, and involve about 14 visits to the study centre, plus 8 phone visits. Study visits to the doctor’s office will involve collection of health information including: height, weight, blood pressure, heart rate, and collected blood samples.

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Heart Failure
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Why Take Part In a Clinical Study?

Regulatory agencies like Health Canada, Australia's Therapeutic Goods Administration and the FDA require that Clinical Research Trials be conducted in order to develop new treatments, preventions and devices for diseases or conditions. Clinical Research Trials are also referred to as Clinical Studies or Clinical Trials. read more