Heart Failure-Kidney Disease Research Trial (22 Weeks)

Adults aged 21 years or older with a diagnosis of stable symptomatic heart failure (NYHA class II-III), and a medical history of typical symptoms and signs of heart failure who are currently receiving loop diuretic treatment, may qualify to participate. Individuals must have documented LVEF (left ventricular ejection fraction) below 55% measured within the last 12 months prior to screening. The study is looking for heart failure patients who have chronic kidney disease (with an estimated glomerular filtration rate ≥30 and ≤60 mL/min). Stable background treatment for heart failure, hypertension, diabetes mellitus, or renal disease for at least 3 weeks prior to randomization is required.

Participants will receive oral medication (investigational study drug and dapagliflozin), either in combination, alone or as placebo. Study medication and study-related procedures will be provided at no cost. Reimbursement for study-related expenses may be provided.

Length of study participation will last about 22 weeks and involve about 11 visits to the study centre.

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Heart Failure
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All information about you will be kept confidential.

If there are no active studies for your condition, we will keep your information and contact you when a new study starts in your area.

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Why Take Part In a Clinical Study?

Regulatory agencies like Health Canada, Australia's Therapeutic Goods Administration and the FDA require that Clinical Research Trials be conducted in order to develop new treatments, preventions and devices for diseases or conditions. Clinical Research Trials are also referred to as Clinical Studies or Clinical Trials. read more